研究人员聚焦重复性头部创伤后，脑周细胞对炎症反应的作用，发现 PDGF-BB 可减轻炎症，为 TBI 治疗提供新思路。 在大脑这个神秘的 “小宇宙” 里，神经炎症和血脑屏障（BBB）的破坏是许多神经系统疾病的 “导火索”，就像一场失控的 “小风暴”，会给大脑 ...

It can form either a homodimer (PDGF-BB) or a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), with the dimers linked by disulfide bonds. Mutations in PDGFB have ...

其中，华芢生物的核心产品 Pro-101-1 和 Pro-101-2 是重组人血小板衍生生长因子 -BB ( “ rhPDGF ... 临床开发进度最快的 PDGF 候选药物，有望成为中国 ...

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...

PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...

The study further demonstrates that OTUB1 is necessary for platelet-derived growth factor-BB (PDGF-BB)-induced proliferation, phenotype switching, and migration of HASMCs. RNA sequencing and mass ...