Injectable antibodies targeting PCSK9 have failed to take off as expected in the cholesterol-lowering market, but Merck & Co hopes to do much better with an oral alternative. MK-0616 has been ...

AstraZeneca has taken the decision not to move a PCSK9-targeting antisense drug licensed from Ionis into a phase 3 programme, removing a competitor to Novartis' rival therapy Leqvio. Like Leqvio ...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that binds to the LDL receptor on hepatocytes, promoting its internalization and degradation within the cell. [Repatha package ...

PCSK9, which mediates post-translational destruction of LDL receptors, is raised in HoFH and is further raised by statins. LDL-C, following apheresis, quickly rebounds due to increased synthesis ...

Your healthcare team can best advise you on different medications and supplements that may help lower cholesterol levels, from statins to PCSK9 inhibitors to natural remedies like garlic and red ...

1 Lombardo and his team first looked into connecting protein fragments known to epigenetically silence genes to a DNA binding domain protein programmed to specifically bind Pcsk9. After testing the ...

Epigenetic editing is a promising method for gene regulation in vitro and in vivo, allowing precise control of gene expression without altering the DNA sequence, thereby minimizing genotoxic risks.

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This could soon be a thing of the past as a one-time injection could potentially silence the gene responsible for cholesterol, PCSK9. A new study found this worked just as well as current ...

Notably, a single dose of ELXR using a newly identified repressor domain achieved ~90% repression of PCSK9—a key driver of dyslipidemia—lasting at least 150 days in non-human primates.

VERVE-102 is a novel, in vivo, investigational base editing medicine designed to be a single course treatment that permanently turns off the PCSK9 gene in the liver and durably reduces disease ...