PARP-1 is an enzyme directly involved in repairing single-stranded DNA breaks. It senses single-stranded DNA breaks through a zinc-finger DNA-binding domain, binds to the sites of breaks and ...

Figure 1: Domain architecture of the classic poly-ADP ... Figure 2: Classification of the poly-ADP-ribose-polymerase (PARP) family according to the structural model proposed by Kleine et al.7 ...