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克隆气道基底祖细胞通过再上皮化修复纤维化肺
在此研究中,同济大学附属东方医院再生医学研究所等单位的研究人员发现,在小鼠和猴子模型中,气道基底层的 KRT5+ P63 + 祖细胞在纤维化损伤后可进入肺泡区域。借助自动化培养系统,研究人员从 44 名患有不同肺部疾病的供体中克隆并鉴定了气道基底祖细胞。
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