有很多朋友好奇我们在研究前列腺癌时，如何使用或者构建动物模型。今天就和大家介绍一种我们常用的小鼠模型TRAMP小鼠，通过这种鼠了解一些特殊的前列腺癌。前列腺癌常用小鼠模型常见模型主要包括异种移植模型和基因小鼠模型。异种移植模型将人前列腺癌细胞或患者来 ...

E2F is released from the pRB/E2F complex with ... The increased expression of Hsp90 is crucial to tumorigenesis involving the loss of p53 function, and the higher expressions of the proto ...

2025年2月18日，一篇新的研究论文发表在Oncotarget，第16卷，题为“端粒酶永生人类细胞中强大的p53表型和潜在的下游靶标”。 2025年2月18日，《Oncotarget》杂志第16卷发表了一篇题为“端粒酶永生化人类细胞中稳健的p53表型及潜在下游靶点”的研究论文。来自西德尼 ...

What is the significance of its crosstalk with other pathways, such as the E2f–Rb pathway? How is one p53-dependent response selected from many possible options? One thing is clear: p53 is ...

p53 normally functions to gauge DNA damage, halt cell-cycle, and activate the apoptotic pathway. The E7 viral oncoprotein has been shown to bind to retinoblastoma protein (Rb), releasing E2F from ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.