E2F is released from the pRB/E2F complex with ... The increased expression of Hsp90 is crucial to tumorigenesis involving the loss of p53 function, and the higher expressions of the proto ...

What is the significance of its crosstalk with other pathways, such as the E2f–Rb pathway? How is one p53-dependent response selected from many possible options? One thing is clear: p53 is ...

p53 normally functions to gauge DNA damage, halt cell-cycle, and activate the apoptotic pathway. The E7 viral oncoprotein has been shown to bind to retinoblastoma protein (Rb), releasing E2F from ...