For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these ... Runt domain (a small β-strand) and p53 (a pair of antiparallel β-strands).

Because Mediator interacts with both DNA-binding TFs and the general transcription machinery (including pol ... Suppression of p53 response by targeting p53–Mediator binding with a stapled peptide.

is a small molecule that blocks the interaction between the p53 protein – which suppresses cancer by stimulating the expression of genes that are involved in DNA repair and programmed cell death ...