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缺氧诱导的 ATF3 通过 P4HA1 促进乳腺癌侵袭:一条潜在的治疗新靶点
为探究乳腺癌对缺氧的适应机制,研究人员研究 HIF1α-ATF3-P4HA1 轴,发现其促进癌细胞侵袭,为治疗提供靶点。 在肿瘤的 “小世界” 里,乳腺癌细胞正经历着一场特殊的 “考验”—— 缺氧。肿瘤不断生长,内部的代谢和血管出现异常,导致缺氧区域逐渐形成。
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