虽然Wnt通路在肿瘤的发生和发展中起着至关重要的作用，但越来越多的研究报道其受其他通路的调控，包括KRAS、磷脂酰肌醇3-激酶- akt和Notch通路。

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...