The Notch family of transmembrane receptors comprises four members ... Interestingly, it was shown to also act by an anti-angiogenic mechanism, in both in vitro and in vivo models.

Jagged 1-Notch2 signaling and a distinctive progenitor-like gene expression profile. Within the limitations of the PDX system they used, their methods are state-of-the-art, their data are strong and ...

While platforms like chimeric antigen receptors and synthetic Notch receptors offer novel ... These systems are also constrained by their activation mechanisms and output options.