Jagged 1-Notch2 signaling and a distinctive progenitor-like gene expression profile. Within the limitations of the PDX system they used, their methods are state-of-the-art, their data are strong and ...

This pathway, called the Delta-Notch signaling pathway, enables neurons to guide the differentiation of a class of progenitors—immature cells that will differentiate into specialized types ...

It is known that Notch signalling in the thymus drives the differentiation of T cells from lymphoid progenitors that have migrated there, but the precise molecular mechanisms governing the ...

Researchers from the Organoid group at the Hubrecht Institute have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause ...

"Because we showed that Notch, a receptor in a highly conserved cell signaling pathway, was involved in the process, this ...

Petsko and Wu will be recognized with the other 2025 fellows at the ASBMB annual meeting in Chicago in April. Spyros ...

Many signaling pathways, including homeobox (HOX), Notch, Hedgehog and Wnt/β-catenin, have been implicated in HSC self-renewal. These developmental regulators bind to cell-surface receptors ...