It is known that Notch signalling in the thymus drives the differentiation of T cells from lymphoid progenitors that have migrated there, but the precise molecular mechanisms governing the ...

Moreover, it also decreased cell size and increased apoptosis ... as well as other indications linked to dysregulated Notch signalling.

为了揭开这些谜团，俄罗斯科学院细胞学研究所等单位的研究人员展开了深入研究，并在《Cell Communication and Signaling》期刊上发表了题为 “Endothelial - mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling” ...

This pathway, called the Delta-Notch signaling pathway, enables neurons to guide the differentiation of a class of progenitors—immature cells that will differentiate into specialized types ...

Researchers from the Organoid group at the Hubrecht Institute have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

"Using cell-type specific reporter organoids and CRISPR-mediated genetic modifications, we found that the Notch signaling pathway and a master regulator named SPIB are crucial for these cells ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

Many signaling pathways, including homeobox (HOX), Notch, Hedgehog and Wnt/β-catenin, have been implicated in HSC self-renewal. These developmental regulators bind to cell-surface receptors ...