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Drug Discov. 7 426–437; 2008). Increased levels of glutamate have been found in the frontal cortex of patients with MDD, and the non-selective NMDA receptor antagonist ketamine has shown ...
Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.
There are now ketamine clinics nationwide where the drug is given intravenously to treat depression. Like a lock and key, ketamine binds to the brain via N-methyl-D-aspartate (NMDA) receptors.
NMDA receptors, members of the excitatory ionotropic glutamate receptor family, are essential to these processes. They regulate the strength of synaptic connections, playing a critical role in ...