U-II was found to increase afterload and reduce myocardial contractility. Its effect at high concentrations is best rationalized by myocardial ischemia. Using the calculations of Sunagawa et al.

Lignocaine has no effect on supraventricular tachycardia (SVT). Like most antiarrhythmic drugs, lignocaine depresses myocardial contractility, and toxic levels can produce paraesthesia, drowsiness, ...

[11] Beta blockers, including carvedilol, also decrease heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its a ...

The patent filing expands upon data obtained from animal model testing and the istaroxime human clinical trials in acute heart failure (AHF) and early cardiogenic shock (ECS), including the latest ...

Clinical feature in adults Transient depression of myocardial contractility; myocardial necrosis (cTnT elevation); arrhythmia Dilated cardiomyopathy; arrhythmia Dilated cardiomyopathy; arrhythmia ...