研究人员为开展此项研究，主要运用了以下关键技术方法：从 TARGET 和 FerrDb 数据库获取数据，运用 R 语言软件进行差异分析，筛选出相关差异表达基因（DEGs）；通过单变量 COX 分析、Lasso 回归分析和多变量 COX 分析构建预后模型并计算风险评分；利用 CIBERSORT 分析高风险（HR）和低风险（LR）人群免疫细胞浸润（ICI）差异；采用细胞实验和实时荧光定量 ...

撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

研究针对 MYCN 扩增型神经母细胞瘤治疗难题，探究 FAM13A 与 N-Myc 作用，发现 FAM13A 或为潜在治疗靶点。 研究背景：攻克难题，探索新靶点 神经母细胞瘤（Neuroblastoma，NB）是一种常见于婴幼儿时期的神经内分泌肿瘤，起源于神经嵴细胞。它在儿童癌症相关死亡中占 ...

Neuroblastoma, an aggressive malignancy originating from neural crest cells, accounts for 15% of cancer-related deaths in children. Treatment strategies include systemic chemotherapy, radiation or ...

MWANZA: The Junior Council members in Nyamagana District, Mwanza region, have made an impassioned plea for schools ...

However, dysregulation of MYC, such as amplification of MYCN, is associated with tumorigenesis, especially for neuroblastoma. MDM2, on the other hand, is one of the most frequently studied ...

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We focus on the role of the MYCN oncogene, since aberrant expression of MYCNis very significantly associated with high-risk in all three diseases and implies that they may have a common cell-of-origin ...