撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

MWANZA: The Junior Council members in Nyamagana District, Mwanza region, have made an impassioned plea for schools ...

为解决 MYCN 扩增神经母细胞瘤治疗难题，美国肯塔基大学研究人员开展 GMDS 相关研究。发现 GMDS 影响肿瘤核心岩藻糖基化和肿瘤发生，2 - FF 可抑制肿瘤生长。该研究为治疗提供新思路，值得科研读者一读。 美国肯塔基大学（University of Kentucky）的 Beibei Zhu、Michelle ...

However, dysregulation of MYC, such as amplification of MYCN, is associated with tumorigenesis, especially for neuroblastoma. MDM2, on the other hand, is one of the most frequently studied ...

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We focus on the role of the MYCN oncogene, since aberrant expression of MYCNis very significantly associated with high-risk in all three diseases and implies that they may have a common cell-of-origin ...

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