Their paper ran in the February 5 Science Advances. Microglia overloaded with lipids choke on Aβ in APP knock-in mice. Depleting the fat-storage-associated protein FIT2 reduced lipid droplet formation ...

Toxic lipid secretion: The ISR pathway in microglia was shown to drive the synthesis and release of harmful lipids that contribute to synapse loss, a hallmark of Alzheimer's disease.

These microglia then mount an inflammatory response ... More information: Yajuan Li et al, Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK, Cell Metabolism ...

Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV Jr, Walther TC. Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol ...