Daily oral treatment with T-614, a member of the methanesulfonanilide family of cyclo-oxygenase 2 inhibitors, might be an alternative to weekly methotrexate therapy for rheumatoid arthritis (RA).

Patient 1 suffered mouth ulcers which settled despite continuation of methotrexate. Patient 4 had impairment in renal function which improved with dose reduction. Patient 5 had nausea; patient 15 ...

Methotrexate sodium 2.5mg; scored tabs. Be fully familiar with this drug's toxicity before use. Obtain baseline and monitor CBCs for myelosuppression, and hepatic, renal and pulmonary function ...