Daily oral treatment with T-614, a member of the methanesulfonanilide family of cyclo-oxygenase 2 inhibitors, might be an alternative to weekly methotrexate therapy for rheumatoid arthritis (RA).

It is an isoxazole derivative and its active metabolite, teriflunomide (formerly ... Leflunomide, like methotrexate, has a role in RA treatment... As the goal of RA treatment is to induce disease ...

Nat Clin Pract Rheumatol. 2007;3(1):26-34. Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily ...