methimazole or with propylthiouracil and, if dose-related, can lower doses than currently administered be prescribed without unduly affecting the rate of restoration of euthyroidism? The largest ...

OBJECTIVE: To evaluate the evidence supporting the use of propylthiouracil (PTU) versus methimazole for the treatment of Graves' disease during pregnancy. DATA SOURCES: An English-language ...

Propylthiouracil therapy should be discontinued in children in favor of alternative approaches, say US researchers, after a systematic and comparative evaluation of the adverse events associated ...

However, they are not completely safe to use during pregnancy as methimazole increases risk of neonatal malformations and propylthiouracil increases risk of maternal hepatotoxicity ...