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Reducing DNA repair protein levels to target root cause of Huntington's disease
Among the DNA repair genes identified, MSH3 has emerged as a particularly promising therapeutic target. MSH3, a key component of the mismatch repair system, recognizes and attempts to repair ...
ALZFORUM29d
Could Taking Down a DNA Repair Protein Stave Off Huntington’s?
In the February 12 Science Translational Medicine, they reported that taking down MSH3, a DNA repair protein, nipped CAG expansion in the bud. The DNA repair protein MSH3 promotes the growth of CAG ...
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Latus Bio Announces Data Presentations in Support of its Preclinical Huntington’s Disease Gene Therapy Program
One presentation will focus on a novel computational model derived by Latus that is aimed at predicting the effects of knockdown of the DNA repair enzyme MSH3 on reducing somatic instability and ...
Medical Xpress1mon
Reducing DNA repair protein levels to target root cause of Huntington's disease
Get Instant Summarized Text (Gist) Lowering MSH3 protein levels can suppress CAG repeat expansion in Huntington's disease, potentially slowing disease progression. Using a patient-derived neuronal ...