Our findings show that micromolar EGCG inhibits tumor cell invasion and directly suppresses the activity of MMP-2 and MMP-9, two of the proteases most frequently overexpressed in cancer and ...

MMPs have garnered attention as potential therapeutic targets for conditions like cancer, cardiovascular diseases ... Sino Biological is actively contributing to MMP research by providing a ...

The activity of the MMPs is regulated by their association with four MMP inhibitors called TIMP1–4, which determine the balance between tumor growth inhibition and metastasis. [65] Therefore ...

DC101 reduced basement membrane thickness on days 2 and 5; coadministration of an MMP inhibitor completely abolished this effect. VEGFR blockade temporarily normalizes tumor vessel walls ...