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促进脊髓损伤修复新策略:小胶质细胞向心迁移与长期留存的关键作用
研究人员为解决脊髓损伤(SCI)修复难题,开展小胶质细胞相关研究,发现共注射 CX 3 CL1 和 M-CSF 可促进其向心迁移与留存,助力 SCI 修复。 CX3CR1 受体的作用 :在 CX 3 CR1 -/- 小鼠中,联合注射 CX 3 CL1 和 M-CSF 的有益效果被阻断,这表明该联合治疗的效果依赖于 CX 3 CR1 受体。
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