The 10-year predicted risk of first stroke was calculated according to the Framingham Stroke Risk Score at baseline and after a mean of 94 ± 24 days of losartan (± hydrochlorothiazide [HCTZ ...

losartan (100 mg/day); and losartan (100 mg/day) plus hydrochlorothiazide (25 mg/day). Proteinuria was reduced by 22% from baseline with the low-sodium diet alone and by 30% with losartan alone.

The ratio of ARB to ARB-plus-hydrochlorothiazide prescriptions was 1.57:1.0. Persons for whom losartan was prescribed were significantly more likely than were other ARB users to take the drug more ...