The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...
The mechanism of how synergistic H-bonds potentiate ligand binding to a receptor is shown. This material relates to a paper that appeared in the March 25, 2016 issue of Science, published by AAAS.