Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

Thus far, one antibody (BIL010t; Biosceptre) that targets a nonfunctional form of the ligand-gated ion channel P2X purinoceptor 7 has reached clinical trials for the treatment of basal cell carcinoma.

Their findings are published in Science Advances. Cys-loop receptors are ligand-gated ion channels with two domains connected by a short linker. The top domain is located extracellularly ...

Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion ...

More information: Di Lu et al, Ligand-channel-enabled ultrafast Li-ion conduction, Nature (2024). DOI: 10.1038/s41586-024-07045-4 Chong Yan et al, Tiny sheaths of solvent boost battery performance ...