Every kinase recognizes a specific linear motif around a serine, threonine or tyrosine. The presence of this motif, however, is not enough to unequivocally link a kinase and a protein substrate.

The surrounding sequence context, or motif, is in turn responsible for the ... phosphotyrosine-based motifs consisting of 50 tyrosine kinase substrate motifs, 19 tyrosine phosphatase substrate ...