In the case of GPCRs, internalization involves serine/threonine phosphorylation of agonist-occupied receptors on the third intracellular loop ... STE11, activation may involve another kinase ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... Constitutive ALK activity in cancers results in the activation of several downstream pathways that are shared with other tyrosine ...