TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium ... to those with rifampicin and isoniazid during the same period.

"We discovered some previously unreported mechanisms," Yang said ... identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis, Nature Communications ...

These data substantiate the need for rapid and reliable methods for drug-susceptibility testing (DST) of Mycobacterium tuberculosis ... to a lower extent, isoniazid resistance), even when used ...