以往，研究人员常用滚环扩增（Rolling Circle Amplification，RCA）结合桑格测序（Sanger sequencing）的方法来研究 CRESS-DNA 病毒。这种方法虽然在揭示病毒多样性方面发挥了重要作用，但存在诸多弊端。它操作繁琐，需要大量的实验室工作，耗费时间长。尤其是在面对多组分病毒或病毒共感染的情况时，效果不佳，很难准确克隆出每个病毒组分，对于低丰度的 DNA ...

Thus, beneficial DNA changes do not happen more often simply ... although such mutations are usually no longer subsumed under the label indel. At this high level, it is also possible to invert ...

It identifies DNA and RNA biomarkers from the same total nucleic acid input. Image Credit: Roche Sequencing and Life Science The prevalence of SNV and InDel alleles in DNA readings is consistent ...