When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

The CD2-CD58 axis is associated with the regulation of autoimmune diseases, immune evasion of tumors, antiviral responses, and immune rejection, and targeted therapies for this have been developed.

Deka Biosciences’ DK210 (EGFR) Diakine TM accumulates in the immune synapse after it binds the EGF receptor on the tumor cell surface and the cytokine receptors on the T cell. This localization ...

However, as the subcapsular sinus and conduit network limit the free diffusion of larger antigens (such as immune complexes, particulates, bacteria or viruses), their access to follicular B cells ...

The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.

Led by first author Dr. Ahmed Gad, postdoctoral associate in Ahmed’s lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological ...

Killer lymphocytes destruction of infected or transformed target cells: Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells play a central role in immune responses against intracellular ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer. Investigators from Baylor College of ...