This image shows a reconstitution of nephron structures by propagated nephron progenitors derived from human iPS cells. Yellow arrowheads: glomeruli, Black arrowheads: renal tubules. Scale bar ...

Genetic studies performed in humans and mutant mice have implicated a number of critical genes, in utero environmental factors and molecular mechanisms that regulate nephron endowment and kidney size.

The higher-order structure of the kidney reconstructed from mouse ES cells (green: collecting tube, red: nephron progenitor cells). Trestle Biotherapeutics is partnering with Dr. Ryuichi ...