Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear ...

IL-12 is a powerful cytokine, a type of protein that acts as a chemical messenger, that plays a key role in initiating the body’s natural immune response. Several studies of IL-12 ...

A new study reveals that IL-12, an inflammatory molecule, accelerates Alzheimer’s disease by damaging brain cells and preventing plaque clearance. Blocking IL-12 in mice halted disease-related changes ...

When interleukin-12 is added to the cell culture, it leads to a significant reduction in nerve fibers (pink) and oligodendrocytes, and thus to a decline in myelin (white).

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T H 1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 ...