Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

Still, BLT- or FLC-humanized mice have some limitations (difficulties in obtaining fetal tissues; low throughput) and are based on NOD-SCID recipient mice that develop lethal thymomas with age.

Ray Lambert looks at the potential of humanized FcRn mice for evaluating the pharmacokinetics of mAbs. Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human ...

Researchers at the Duke Human Vaccine Institute successfully created an HIV vaccine candidate that guides key immune cells ...

Most clinically relevant T-cell receptor (TCR)-engineered T cells are typically tested in immunocompromised mice, allowing human T-cell engraftment but failing to replicate the complex interactions of ...

Researchers have described the development of a novel murine model of glioblastoma established with a patient-derived xenograft (PDX) in humanized mice that harbored an almost complete human immune ...

Anticipated 2025 milestones include: declare two in vivo development candidates, one in HSCs and one in liver; present further in vivo HSC data; present in vivo data in one liver indication; establish ...

Biomedical researchers at Ohio University have received National Institutes of Health (NIH) funding to investigate the role ...

Editas Medicine (EDIT) announced its three-year strategic priorities, anticipated 2025 key milestones, and new in vivo preclinical proof of ...