The human immune system recognizes murine mAbs as foreign material, producing human anti-mouse antibodies (HAMAs ... and are less prone to HAMA reactions. If mAbs were to become a class of ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in ...

the clinical application of mouse monoclonal antibodies is limited by the human anti-mouse antibody (HAMA) response. Humanization of mouse monoclonal antibodies or alpaca nanobody by genetic ...

The first mouse-derived antibodies fell foul because of human anti-mouse antibody reactions evoked in patients. The most recent disappointment was suffered by Corixa (Seattle, WA) on March 19 ...