An abnormal development of the forebrain, holoprosencephaly, is the most common cranial abnormality in infants with Trisomy 13. The embryology and implications of holoprosencephaly are described.

Microarray analysis identifies more chromosome abnormalities than traditional ... was identified and is likely the cause of the holoprosencephaly seen in the fetus.

“In the second image, holoprosencephaly occurred in one ... where aging eggs might result in an extra chromosome 13, known as trisomy 13 or Patau Syndrome," she said. She added that certain ...