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铜死亡再登顶刊:我国学者揭示HIF-1α驱动癌症的铜死亡抵抗
铜死亡(Cuproptosis)是一种新近发现的细胞死亡方式,其发生机制与细胞内铜离子稳态失衡及蛋白质脂酰化过程的异常调控密切相关。具体而言,铜离子过载可导致线粒体三羧酸循环的关键酶(例如DLAT)的脂酰化修饰紊乱,引发线粒体 功能障碍 ...
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