Jazz said that Defitelio is a potentially curative treatment for hepatic veno-occlusive disease (VOD) with renal or pulmonary dysfunction, following haemotopoietic stem-cell transplantation (HSCT).

Defibrotide sodium is under clinical development by Jazz Pharmaceuticals and currently in Phase I for Coronavirus Disease 2019 (COVID-19) Pneumonia.

Pulmonary veno-occlusive disease: not recommended ... Predisposition to priapism. Severe hepatic impairment. Active peptic ulcer. Bleeding disorders. Elderly. Pregnancy. Nursing mothers.