在骨髓中，myHSCs和淋巴系造血干细胞（lyHSCs）的数量对比进一步显示了Sema4A缺失对髓系细胞的过度偏向（g、h）。特别是髓系前体细胞（MyPro）和红系前体细胞（CFU-E）的数量变化，也支持了Sema4A缺失与髓系扩展的关系。

Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as ...

In a recent study, scientists have introduced an innovative imaging technique that provides an unparalleled view of the bone marrow’s intricate structure, focusing on leptin receptor-expressing (LepR+ ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Transplanted cells create a healthy blood-forming system by regenerating hematopoietic cells in the bone marrow. While patients have reduced blood cell counts and depleted immune cells, they are ...

Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...