A pivotal experience in a Hopkins lab inspired Roger Hajjar, '86, to forge a career at the intersection of engineering and ...

Heart attacks are dangerous not just because of the initial event, but the long-term damage afterwards. Now scientists have ...

Benefiting from technological and conceptual groundwork and positive early data, gene therapies are advancing in the clinic ...

Heart failure has historically been irreversible, but the outcome of a new study suggests that could someday change. At the University of Utah, scientists used a new gene therapy that was shown to ...

Previous attempted therapies for heart failure have shown improvements to heart function on the order of 5-10%. cBIN1 gene therapy improved function by 30%. "It's night and day," Shaw adds.

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate ...

For the gene therapy, researchers placed an extra copy of the cBIN1 gene into a hollowed-out virus, then injected the virus into the four pigs. The virus moved through the bloodstream to the heart ...

In addition, transient VEGF expression after adenoviral gene transfer in the heart only induces a short-lived angiogenic response 12. Inhibition of VEGF during active angiogenesis halts vascular ...

Scientists from the University of Colorado Anschutz Medical Campus noticed a curious pattern: midazolam might be connected to ...

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves ...