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Nature Genetics:从守护者到叛徒——如何重塑失职的TP53基因?
癌症背后的分子机制一直是科学研究的热点。在癌症的众多驱动因素中,TP53基因被誉为“基因组的守护者”,是人类体内最重要的肿瘤抑制基因之一。然而,这位“守护者”也常常成为癌症发展的“叛徒”,数据显示,大约50%的癌症患者都携带TP53基因的突变。这些突 ...
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