Chronic hepatitis B virus (HBV) infection continues to pose a major global health threat. The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular ...
It was subsequently found to drive degradation of subunits in a transcriptional repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...
Figure 2: Dnmt1 686–812 represses transcription in a TSA-sensitive manner and has the ability to interact with the HDAC1 deacetylase. Figure 3: The Dnmt1-interacting region of HDAC1 associates ...
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