Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

A key part of the BBB is a carbohydrate-rich layer called the glycocalyx, which comprises proteoglycans, glycoproteins, and ...

Bottlebrush Barrier. The glycocalyx layer (purple, left) that coats brain blood vessels consists of numerous glycoproteins, ...

Aging depletes the brain’s protective sugar shield, weakening defenses and fueling cognitive decline, but restoring key ...

decided to focus on a mucin-rich layer called the glycocalyx, which lines blood vessels. Shi and her colleagues looked at what happens to the glycocalyx in the brain as mice age. “The mucins on ...

"The glycocalyx is like a forest," Shi explains ... but they may be missing the roles that sugar molecules play, Bertozzi ...

Shi was able to demonstrate that in this sugary layer called the glycocalyx, branched glycoproteins called mucins are an important component. Shi also observed that the number of mucins compared ...

Researchers at the University of Gothenburg, Sweden, have uncovered a critical mechanism that may pave the way for innovative treatments for Crohn’s disease. Their findings center on repairing the ...

Stanford scientists discovered that sugar chains on brain cells, called the glycocalyx, degrade with age, weakening the blood ...

Epithelial cells that line the small intestine are protected by a carbohydrate-rich layer called the glycocalyx, which prevents bacteria from coming in direct contact with the cells. A key ...