The US Food and Drug Administration (FDA) has granted breakthrough therapy designation to Grin Therapeutics’ radiprodil for ...

For most of us, getting less than seven hours of sleep translates into grogginess, sluggish thinking, and an overwhelming ...

The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors. This study is a major step toward the ultimate goal of treating fragile X syndrome (FXS), an ...

A neuroanatomical minimal network model was revisited to elucidate the mechanism of salt concentration memory-dependent chemotaxis observed in Caenorhabditis elegans. C. elegans memorizes the salt ...

Glutamate acts at NMDA receptors in cultured rat forebrain neurons to increase the intracellular free calcium concentration. Although concurrent inhibition of mitochondrial calcium uptake ...

Researchers identified a rare genetic mutation in two schizophrenia patients that increased schizophrenia-related behaviors ...

NMDA receptors, members of the excitatory ionotropic glutamate receptor family, are essential to these processes. They regulate the strength of synaptic connections, playing a critical role in ...

Now, new research from the Warren Center for Neuroscience Drug Discovery (WCNDD) offers hope. Scientists have identified a ...

View Full Profile. Learn about our Editorial Policies. When I expressed the different protein constructs in neuron cells in culture, I demonstrated that these C-terminal tails determined the ...

Sleep's role to down-scale glutamate, excitatory, frontal cortical synapses is extended to include an up-scaling of metaplastic LTP potential, in recovery from prolonged waking induced saturation of ...

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with ...