为探究衰老如何调节蛋白质翻译后修饰（PTMs）影响机体抗病毒防御能力，研究人员开展 STAT1 修饰相关研究。发现衰老影响 STAT1 的 Kbhb 和 O-GlcNAc 修饰，小分子化合物和果糖可干预。该研究为提升老年人抗病毒能力提供策略，值得一读。 2025年，中国科学院的研究 ...

The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.

More information: Sara Formichetti et al, Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo, PLOS Genetics (2025). DOI: 10.1371/journal.pgen.1011507 ...

This method uses advanced solid-phase materials and bioorthogonal chemistry to simultaneously identify multiple glycosylation types, including N-glycosites, O-GlcNAc sites, and O-GalNAc sites ...