生物通24 天
衰老与抗病毒防御新解：STAT1 修饰转换如何左右老年人免疫防线？
为探究衰老如何调节蛋白质翻译后修饰（PTMs）影响机体抗病毒防御能力，研究人员开展 STAT1 修饰相关研究。发现衰老影响 STAT1 的 Kbhb 和 O-GlcNAc 修饰，小分子化合物和果糖可干预。该研究为提升老年人抗病毒能力提供策略，值得一读。 2025年，中国科学院的研究 ...
Nature2 个月
A sugar-coated switch for cellular growth and arrest
The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.
来自MSN3 个月
Glycans can regulate their own biosynthesis by modifying enzyme activity
Additional experiments suggested that the lectin domain of normal GnT-IVa and GnT-IVb had little to do with the actual formation of the β1-4-GlcNAc branch on substrate glycoproteins. The team ...
来自MSN2 个月
Embryo development hinges on sugar-modified proteins, study demonstrates
More information: Sara Formichetti et al, Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo, PLOS Genetics (2025). DOI: 10.1371/journal.pgen.1011507 ...