Here authors show that NKG7, a lysosomal protein specifically expressed in CD8 + T cells, inhibits mTORC1 function via the lysosomal proton pump, vacuolar ATPase, promoting antitumor activity ...

We describe the differential expression of a set of 20 signature genes in models of infection and autoimmunity that may be useful for future studies on γδ T cell functions. CD8 + T cell ...

董晨教授团队在 Nature Communications 期刊发表了题为：TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8 + T cell activation 的研究论文。

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8 + T cell division for the generation of memory precursor cells.

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and ...

To investigate the intrinsic role of aging on CD8 + T cell function, Prof. Xiao Yichuan's team from SINH and collaborators isolated CD8 + T cells from young and aged mice and then adoptively ...

In autoimmune diseases such as inflammatory bowel disease (IBD), the function of regulatory CD8 T cells (CD8 Treg) is compromised, in part due to the expression of inhibitory KIR receptors ...

Developing effective treatments and understanding how the mechanism of the immune system have always been challenging for ...

Discover a study that describes a host-intrinsic mechanism responsible for the failure of PD-L1 blockade in ovarian cancer.

Proper immune system function is paramount for human survival against infectious disease ... Once acquired infection persists for life requiring continuous life long cellular immunity (CD8 memory T ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic cancer cells.