There is a serious worldwide shortage of recombinant factor VIII, a critical blood-clotting protein that hemophilic patients use to prevent and control their bleeds, according to the National ...

Males who have a mutant copy of the factor VIII gene (F8) will always have hemophilia. In contrast, women are rarely affected by this disease, although they are most often carries of the mutated gene.

It’s caused by mutations in a single gene that contains the instructions our bodies need to produce a protein called Factor VIII, which allows our blood to clot. Some haemophiliacs produce less ...