Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis.

The fms-like tyrosine kinase 3 (FLT3) plays an important role in both normal and malignant hematopoiesis. Activating mutations in the FLT3 receptor can be detected in approximately 30% of acute ...

FLT3 (Fms-like tyrosine kinase 3), also known as FLK-2 (fetal liver kinase 2) and STK-1 (stem cell kinase 1), is a cell surface tyrosine kinase, belonging to a family of growth factor receptors ...