Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been shown to drive oncogenesis in a subset of patients with multiple myeloma. However, epithelial cancers — such as bladder ...

The research delves into how mutations in FGFR2 and FGFR3 affect mandibular bone formation and endochondral bone repair following non-stabilized fractures. The findings reveal that FGFR ...

Achondroplasia risk factors Achondroplasia is caused by a spontaneous mutation in a specific gene called FGFR3. About 98% of cases result from the exact same change in the DNA in this gene.

11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels. In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 ...

For example, some patients with kidney cancer with specific gene mutations may benefit from targeted therapy, while those with stage 4 bladder cancer should check for FGFR3 or HER2 mutations to see if ...